Full Kinetic Characterisation

The binding kinetics determine the affinity of a drug to its target and can impact the coupling efficiency of the drug by affecting the state of equilibrium. Thus binding kinetics help shape the clinical outcomes that are important to patients: efficacy, safety, duration of action, greater tolerability, indication and therapeutic differentiation.

Full kinetic characterization of biomolecular interactions of each compound with the target include the determination of:

on-rate (kon)

off-rate (koff)

affinity (KD)